Noteworthy Chemistry, a product of the American Chemical Society

This week's topics:

1. Thiadiazole derivatives may help treat type 2 diabetes
2. Incorporating melanin enhances polymers’ thermal stability
3. Make β-adrenergic blockers in one pot with an organocatalyst
4. Protocol changes improve a drug synthesis scale-up
5. Organic radicals efficiently emit phosphorescence
6. Fine-tune silk by using protic ionic liquids
7. Solid-state metathesis polymerization makes conjugated polymers

Wanted: Noteworthy Chemistry Contributors
If you read the journal literature during the course of your work, ACS is looking for you! Please consider writing informed summaries of newly published articles for Noteworthy Chemistry. If you’re interested, contact ncpw@acs.org for details.

This week's topics:

• These amphiphilic phospholes are mesomorphic and luminescent
• Prepare antiaromatic dications without magic acid
• Use design of experiments to improve a reaction workup
• Household chemicals can destroy chemical warfare agents
• Use atomic force microscopy to study block copolymer surfaces
• Hydrophosphonate olefins to prepare Z-selective Wittig reagents
• Make supramolecular networks from ternary copolymer blends

Wanted: Noteworthy Chemistry Contributors
If you read the journal literature during the course of your work, ACS is looking for you! Please consider writing informed summaries of newly published articles for Noteworthy Chemistry. If you're interested, contact ncpw@acs.org for details.

This week's topics:

1. Couple CO2 and an epoxide to make poly(indenecarbonate)
2. Amphoteric polymers respond to physiological changes
3. Modified polydopamine coatings carry a one–two punch
4. Some of Alfred Werner’s crystal samples show chirality
5. Change a precursor, use cross-coupling to shorten a synthesis
6. Use fluorinated aziridines to make asymmetric 1,3-oxazolidines
7. These compounds fluoresce efficiently in the crystalline state

Wanted: Noteworthy Chemistry Contributors
If you read the journal literature during the course of your work, ACS is looking for you! Please consider writing informed summaries of newly published articles for Noteworthy Chemistry. If you’re interested, contact ncpw@acs.org for details.

This week's topics:

1. Zanamivir phosphonate derivatives combat resistant flu strains
2. Upgrade stereopurity by isolating the unwanted material
3. Substitute fluorine at key sites to improve antitumor drugs
4. Mechanically “unclick” triazole polymers
5. BODIPY molecules self-assemble into NIR–emitting particles
6. Copper nitride crystals remove a fuel-cell roadblock
7. Prepare phenylacetic acids by using iodide-catalyzed reduction

This week's topics:

1. MRSA strains respond to a neomycin analogue
2. Are we defeating cancer?
3. A simplified celecoxib synthesis features direct arylation
4. Use a DABCO salt in an amide coupling reaction
5. An amphiphile exhibits polymorphic self-assembly
6. Confine hierarchically structured materials in porous polyethylene
7. Make diastereopure products from α-trifluoromethyl carbonyls

This week's topics:

1. Cyclo-p-phenylene emissions blue-shift as ring size increases
2. Functional coatings give cellulose fibers a host of properties
3. Should you use an acetyl or benzoyl protecting group?
4. This ladder polymer takes up large amounts of hydrogen
5. Biological materials inspire synthetic multiscale structures
6. White organic light-emitting diodes with long lifetimes
7. Core-extended terrylenes have optically active atropisomers

This week's topics:

1. Use a hypervalent bromine oxidant to make aziridines
2. Carbon dioxide shifts the fluorescence of a host–guest complex
3. Use deuterium NMR to evaluate Lewis acidity
4. The nitrogen flow rate affects a chlorination reaction
5. Detect single DNA molecules
6. Chains and scrolls: new insights into nanopeapod structures
7. Steric crowding induces fluorescence in boron-based dyes

This week's topics:

1. The monomer sequence affects biopolymer degradation
2. Calixarenes support polymetallic lanthanide clusters
3. Here’s a new way to resolve the enantiomers of praziquantel
4. Organize and stabilize block copolymers in a magnetic field
5. String boratabenzeneiron(II) "beads" on polymer chains
6. Familiarize yourself with stem-cell biology
7. Use polymer-supported fluoride ion to degrade nerve agent VX

This week's topics:

1. A single luminophore emits three colors of visible light
2. A noncovalent strategy for multiscale protein fiber assembly
3. pH-sensitive nanoparticles provide site-specific drug delivery
4. The anion controls graphite intercalation in ionic liquids
5. Difluoromethylate a phenol on the multikilogram scale
6. Here's a better way to measure metabolic stability

This week's topics:

1. The first regiospecific synthesis of anti-anthradithiophenes
2. Grow crystallographically oriented, shaped gold microrings
3. Use anti-Markovnikov hydration to make primary alcohols
4. Make aminoquinazolines from o-amino nitriles
5. The inside matters: Tune nanotube assembly, functionalization
6. Morpholinopyrimidine derivatives are potent inhibitors

This week's topics:

1. Control biological and mechanical function in peptide gels
2. Use a one-pot method to make chiral tetrahydro-γ-carbolines
3. Reversibly bend plastic with light
4. Fluorescent nanomicelles act as tumor-targeting bioprobes
5. A hurdle to using two solvents in drug synthesis is removed
6. Benzodipyrrolidone-based polymers for optoelectronic devices
7. Introducing DABSO, a new source of sulfur dioxide

This week's topics:

1. Make poly(ionic liquid)s by cobalt-mediated polymerization
2. Run a hydroformylation reaction in tert-butyl alcohol
3. Prepare thiazolidinones from three components in one pot
4. Self-assembly of large graphene oxide sheets
5. A simple way to trifluoromethylate aromatic heterocycles
6. Go with the flow: Shear forces induce a cubic lipid phase
7. Create telechelic polymers with regioregular morphologies

This week's topics:

1. Use three catalysts to α,α-difluorinate carbonyl compounds
2. Here’s a new way to make self-healing materials
3. Prepare hyper–cross-linked polymers by click polymerization
4. The Appel reaction catalyzed by triphenylphosphine oxide
5. Is PMI a better measure of “greenness” than the E factor?
6. Epoxy resins with polyisobutylene domains